In studies, the most common reason people stopped treatment was due to muscle spasms, diarrhea, and pain in an extremity, like arms or legs. This medicine is usually well-tolerated, but it may infrequently increase your risk of gout or tendon rupture. Bempedoic acid has been shown in studies to decrease LDL-C (“bad cholesterol”) levels and is given in combination with other cholesterol-lowering treatments.Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. It can be an expensive medicine if your insurance does cover it, but the manufacturer, Esperion Therapeutics, may be able to offer financial assistance or a Nexletol copay card for eligible patients. There are currently no generic alternatives for bempedoic acid (Nexletol).Breastfeeding is not recommended with bempedoic acid.However, based on it's mechanism of action, it may cause fetal harm. There are no available data on bempedoic acid use in pregnant women to evaluate for a risk of major birth defects, miscarriage, or other side effects in the mother or fetus.This has happened within 4 weeks of starting treatment and may continue. Elevations in serum uric acid have occurred and may lead to gout.Stop use of bempedoic acid at the first sign of tendon rupture and contact your doctor right away. Symptoms of tendon problems may include pain, swelling, inflammation, and tears of tendons including the arm, shoulder, and back of the ankle (Achilles). You may not be able to use bempedoic acid if you have a history of tendon disorders or tendon rupture. Tendon rupture has occurred in people using bempedoic acid.Taking simvastatin or pravastatin with bempedoic acid may increase your In some cases, you may not be able to use simvastatin or pravastatin with bempedoic acid based upon your statin dose.It is not known if bempedoic acid is safe and effective in people with severe kidney problems including people with end-stage kidney disease who are on dialysis, severe liver problems, or in children under 18 years of age.It is not known if bempedoic acid can decrease problems from high cholesterol, such as heart attacks, stroke, death, or other heart problems.These are listed as some of the most common side effects. Symptoms of the common cold or flu, muscle spasms, back pain, pain in the shoulders, legs or arms, anemia (low red blood cell counts, bronchitis (lung inflammation / infection), increased liver enzymes, or stomach pain.If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Dosing changes of bempedoic acid are not needed when administered with atorvastatin (Lipitor) or rosuvastatin (Crestor), according to the manufacturer.However, greater sensitivity in older patients cannot be ruled out. No differences in safety or effectiveness were observed between patients 65 years and older, and younger patients. No dosage adjustments are recommended based on advanced age.No dosage adjustments are recommended for people with mild to moderate liver impairment, but people with severe liver disease have not been studied.No dosage adjustments are recommended for people with mild or moderate kidney impairment, but there is limited experience in people with severe kidney disease or on dialysis.Is used with other cholesterol-lowering medications like statins, fenofibrate, or bile-acid sequestrants that also help to lower lipids.Taken as one tablet by mouth, once a day.Bempedoic acid is used to lower LDL-C (low-density lipoprotein C) levels in adults with heterozygous familial hypercholesterolemia or established heart disease whose LDL-C levels are still high despite maximally tolerated statin treatment and following a cholesterol-lowering diet.Administration of bempedoic acid with a maximum tolerated dose of a statin (with or without other lipid modifying agents) decreases LDL-C (low density lipoprotein cholesterol or “bad” cholesterol), non-high density lipoprotein cholesterol (non-HDL-C), apolipoprotein B (apo B), and total cholesterol (TC) in patients with hyperlipidemia.It’s a prodrug and is converted to an active drug in the liver. Bempedoic acid belongs to the class of medicines known as adenosine triphosphate-citrate lyase (ACL) inhibitors. It is not a statin drug, but is used alongside statin treatments. Bempedoic acid is a prescription medication used along with diet and other lipid-lowering medicines in adults to help lower high cholesterol.It blocks an enzyme needed to make LDL (“bad cholesterol”). Bempedoic acid works by lowering the production of cholesterol in the liver.Medically reviewed by Leigh Ann Anderson, PharmD.
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